Cellular Entry of Binary and Pore-Forming Bacterial Toxins
نویسندگان
چکیده
منابع مشابه
Cellular Entry of Binary and Pore-Forming Bacterial Toxins
This Special Issue of Toxins, entitled “Cellular Entry of Binary and Pore-Forming Bacterial Toxins,” gives a sense of the recent advances in characterizing the functional and structural aspects of this broad scientific problem that goes beyond the classical field of toxinology and microbiology and spills into the general areas of biochemistry, biophysics, and molecular and cell biology. The con...
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Pore-forming toxins (PFTs) are the most common class of bacterial protein toxin and are important for bacterial pathogenesis. Recent studies have shown that the previous model stating that epithelial cells lyse in response to these toxins and have no defenses against these pores is oversimplified. Rather, it appears that cells have sophisticated mechanisms and signal-transduction pathways with ...
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Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are required for virulence in a large number of important pathogens, including Streptococcus pneumoniae, group A and B streptococci, Staphylococcus aureus, Escherichia coli, and Mycobacterium tuberculosis. PFTs generally disrupt host cell membranes, but they can have additional effects independent of pore formation....
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Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive and Gram negative bacteria. Their mode of action is deceptively simple, poking holes in the plasm...
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ژورنال
عنوان ژورنال: Toxins
سال: 2017
ISSN: 2072-6651
DOI: 10.3390/toxins10010011